On behalf of all the editors, I welcome you to the seventh edition of Nathan and Oski's Hematology of Infancy and Childhood. For more than 30 years this textbook has served as the premier resource for students, clinical fellows, investigators, and practitioners in the field of pediatric hematology. From its inception, David Nathan and Frank Oski sought to relate pathophysiology to the hematologic diseases afflicting children. Their goal was to stimulate bench-to-bedside and bedside-to-bench activities to understand and then treat pediatric hematological disorders. What was not envisioned in those early days was how rapidly the basic biology and genetics underlying the field would develop. With each new edition, the text and the roster of editors have grown. We take this as a healthy sign. So much has been learned in this timeframe that has contributed to improved care of children with hematologic disorders.
The seventh edition of Hematology of Infancy and Childhood represents a further evolution of the life of this organic textbook. We have recruited Sam Lux to join us as an editor in order to incorporate his remarkable insights and vision to the current edition. In prior editions we drew the boundary for the scope of the textbook to encompass hematology per se, both nonmalignant and malignant, despite the reality that we, and others, train clinical fellows in pediatric hematology and oncology. For several editions we provided superficial coverage of pediatric oncology with a single chapter on solid tumors. In the sixth edition, on the urging of Tom Look, an insightful investigator of childhood malignancies, we eliminated this chapter. Though beautifully done by Arnold Altman, it could never fully capture the increasing knowledge base and breadth of pediatric oncology. Reflecting on this history and the extraordinary progress in cancer biology and genetics, we chose to create an entirely new volume devoted to pediatric oncology. Going forward, we present our readers with parallel textbooks: Hematology of Infancy and Childhood and Oncology of Infancy and Childhood.
To meet the daunting challenge of bringing forward a new oncology volume, we invited David Fisher, an extraordinary cancer biologist, physician, and cellist, to join Tom Look as editors for this venture. The goal, as before, has been to join basic pathophysiology and clinical medicine at the hip. The creation of the Oncology volume necessitated moving the chapters on malignant hematology, including the leukemias, from Hematology of Infancy and Childhood. We hope that readers find the new volume as useful and perhaps as inspiring as prior editions of Nathan and Oski. Launching a new venture is never without some missteps. We welcome feedback from our readers on the extent to which these new developments meet the needs of students, investigators, and clinicians in the field. After all, the success of Hematology of Infancy and Childhood and Oncology of Infancy and Childhood cannot be measured in numbers of pages or volumes sold. We will be pleased only if these textbooks provide students, fellows, and faculty with the knowledge and inspiration to move the frontier of pediatric hematology and oncology forward and reduce the burden of disease on children.
This seventh edition of Hematology of Infancy and Childhood has truly been a team effort. I thank the other editors for their dedication to this project. We are grateful to the authors of each chapter for their contributions. Our efforts, however, would be futile if it were not for the hard work, patience, and guidance of our editors at Elsevier, Dolores Meloni and Ann Ruzycka Anderson, and our managing editor, Cathy Lantigua. We appreciate everything they have done.
Finally, we want to express our deep gratitude to those who trained us in academic medicine. This is a glorious field that we have mightily enjoyed. In many ways, this book is our expression of appreciation to them.
- The Authors -
Key Features
- Balances summaries of relevant pathophysiology with clear, practical clinical guidance to help you thoroughly understand the underlying science of diseases.
- Offers comprehensive coverage of all hematologic disorders, including newly recognized ones, along with the latest breakthroughs in diagnosis and management.
- Uses many boxes, graphs, and tables to highlight complex clinical diagnostic and management guidelines at a glance.
- Presents an all-new full-color design that includes clear illustrative examples of relevant science and clinical problems for quick access to the answers you need.
- Provides access to the complete contents online, fully searchable, enabling you to consult it rapidly from any computer with an Internet connection.
Website Features
- Consult the book from any computer at home, in your office, or at any practice location.
- Instantly locate the answers to your clinical questions via a simple search query.
- Quickly find out more about any bibliographical citation by linking to its MEDLINE abstract.
Contents
SECTION I - HISTORY
- Chapter 1 - Pediatric Hematology in Historical Perspective
SECTION II - NEONATAL HEMATOLOGY
- Chapter 2 - The Neonatal Erythrocyte and Its Disorders
- Chapter 3 - Immune Hemolytic Disease of the Newborn
- Chapter 4 - Disorders of Bilirubin Metabolism
- Chapter 5 - Developmental Hemostasis: Relevance to Newborns and Infants
SECTION III - BONE MARROW FAILURE
- Chapter 6 - Anatomy and Physiology of Hematopoiesis
- Chapter 7 - Acquired Aplastic Anemia and Pure Red Cell Aplasia
- Chapter 8 - Inherited Bone Marrow Failure Syndromes
- Chapter 9 - Principles of Bone Marrow and Stem Cell Transplantation
SECTION IV - DISORDERS OF ERYTHROCYTE PRODUCTION
- Chapter 10 - Diagnostic Approach to the Anemic Patient
- Chapter 11 - Megaloblastic Anemia
- Chapter 12 - Disorders of Iron Metabolism and Sideroblastic Anemia
- Chapter 13 - The Porphyrias
SECTION V - HEMOLYTIC ANEMIAS
- Chapter 14 - Autoimmune Hemolytic Anemia
- Chapter 15 - Disorders of the Red Cell Membrane
- Chapter 16 - Pyruvate Kinase Deficiency and Disorders of Glycolysis
- Chapter 17 - Glucose-6-Phosphate Dehydrogenase Deficiency
SECTION VI - DISORDERS OF HEMOGLOBIN
- Chapter 18 - Hemoglobins: Normal and Abnormal
- Chapter 19 - Sickle Cell Disease
- Chapter 20 - The Thalassemias
SECTION VII - THE PHAGOCYTE SYSTEM
- Chapter 21 - The Phagocyte System and Disorders of Granulopoiesis and Granulocyte Function
SECTION VIII - THE IMMUNE SYSTEM
- Chapter 22 - The Immune Response
- Chapter 23 - Primary Immunodeficiency Diseases
SECTION IX - STORAGE DISEASES
- Chapter 24 - Storage Diseases of the Reticuloendothelial System
SECTION X - HEMOSTASIS
- Chapter 25 - Platelets and the Vessel Wall
- Chapter 26 - Blood Coagulation
- Chapter 27 - The Molecular Basis of Fibrinolysis
- Chapter 28 - Clinical and Laboratory Approach to the Patient with Bleeding
- Chapter 29 - Inherited Platelet Disorders
- Chapter 30 - Hemophilia and von Willebrand Disease
- Chapter 31 - Rare Hereditary Coagulation Factor Abnormalities
- Chapter 32 - Inherited Disorders of Thrombosis and Fibrinolysis
- Chapter 33 - Acquired Platelet Defects
- Chapter 34 - Acquired Disorders of Hemostasis
SECTION XI - SUPPORTIVE THERAPY
- Chapter 35 - Transfusion Medicine
SECTION XII - HEMATOLOGIC MANIFESTATIONS OF SYSTEMIC DISEASES
- Chapter 36 - Hematologic Manifestations of Systemic Diseases
- Chapter 37 - Hematologic Manifestations of Systemic Diseases in Children of the Developing World
Appendices: Reference Values in Infancy and Childhood
About the Authors
- Stuart H. Orkin, MD, David G. Nathan Professor of Pediatrics, Harvard Medical School; Chief, Department of Pediatric Oncology, Dana-Farber Cancer Institute; Investigator, Howard Hughes Medical Institute, Boston, Massachusetts.
- David G. Nathan, MD, Robert A. Stranahan Distinguished Professor of Pediatrics, Harvard Medical School; Physician-in-Chief Emeritus, Children's Hospital Boston; President Emeritus, Dana-Farber Cancer Institute, Boston, Massachusetts.
- David Ginsburg, MD, James V. Neel Distinguished University Professor, Departments of Internal Medicine and Human Genetics; Investigator, Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, Michigan.
- A. Thomas Look, MD, Professor of Pediatrics, Harvard Medical School, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
- David E. Fisher, MD, PhD, Professor of Pediatrics, Wigglesworth Professor of Dermatology, Harvard Medical School; Chief, Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts.
- Samuel E. Lux IV, MD, Professor of Pediatrics, Harvard Medical School; Chief Emeritus, Division of Hematology/Oncology, Children's Hospital Boston, Boston, Massachusetts.
Product Details
- Hardcover: 1872 pages
- Publisher: Saunders; 7 edition (December 3, 2009)
- Language: English
- ISBN-10: 1416034307
- ISBN-13: 978-1416034308
- Product Dimensions: 11.1 x 8.9 x 2.5 inches
List Price: $390.00