Medical Lecture Note: Hoffman: Hematology: Basic Principles and Practice 5th Edition (Expert Consult Series)

This volume represents the fifth edition of Hematology: Basic Principles and Practice. The initial concept for this textbook was formulated over two decades ago, and each edition of the book has evolved in response to the dramatic advances that have occurred in hematology. This evolution is a testimony to the continued energy of the editors, contributors, and readers of the book. The editorial board has incorporated scientific and diagnostic and therapeutic advances in hematology into each edition so that that the practicing hematologist, laboratory researcher, clinical researcher, student, or healthcare professional might more easily keep pace with this field and more effectively practice their craft. This text is intended to make modern hematology an exciting discipline that can be easily accessed by its diverse readership.

There have been several changes in the leadership of the book that have resulted in this fifth volume moving in new and exciting directions. Six of the editors of the previous edition, Ronald Hoffman, Edward J. Benz Jr., Sanford J. Shattil, Bruce Furie, Leslie E. Silberstein and Philip McGlave, have enthusiastically participated in the fifth edition. Remarkably, Drs. Hoffman, Benz, Shattil, and Furie have been with the book from its conception. Dr. Harvey J. Cohen, who was one of the editors of each of the previous four editions, unfortunately was not able to participate in this edition due to other responsibilities. Dr. Cohen made numerous important contributions to each of the previous editions and was an important ingredient to the success of this textbook. Each of the editors would like to express their sincere appreciation for his efforts. Dr. Cohen has been replaced by Dr. Helen Heslop from the Baylor College of Medicine in Houston, Texas. Dr. Heslop is an outstanding, internationally renowned scientist, pediatrician, and hematologist. Her participation has led to further improvements and expansion of chapters dealing with clinical immunology, pediatric hematology, pediatric stem cell transplantation, and gene therapy—additions that have substantially improved this edition.

The editorial board recognizes the pivotal role that hematopathology plays in the practice of modern hematology. This requires a close interaction between the clinician and the hematopathologist, each using their various clinical tools to serve patients with hematologic disorders. To improve the number and quality of hematopatology images in the fifth edition, we have invited Dr. John Anastasi, a well-respected hematopathologist from the University of Chicago, Pritzker School of Medicine, to join our editorial board as Hematopathology Image Consultant. Dr. Anastasi has reviewed each chapter and added or replaced photomicrographs with more illustrative images. One just has to thumb through this volume to gain a sense of the contribution that Dr. Anastasi has made to the fifth edition.

Another modification that is being implemented in this edition deals with references in each chapter. In previous editions, a significant proportion of the pages of many chapters were devoted to long lists of references. Such referencing of the literature is critical to the maintenance of the book as an academic enterprise. In order to retain this feature, a complete reference list of each chapter is provided on the Expert Consult Website that accompanies this volume. This strategy has allowed us to expand the actual number of pages devoted to useful text and to provide a short list of 20–30 general references at the end of each chapter. This modification has allowed us to maintain this textbook as a single volume. We hope that this compromise will be received in a favorable manner by our readership and that the website containing the full reference list will be accessible and useful.

Hematology: Basic Principles and Practice has become a leader among other textbooks dealing with the same subject matter. The close interaction between the members of the editorial board has, in the creation of each edition, led to novel concepts that have subsequently been incorporated into a number of other medical textbooks. As we finish this fifth edition of our book, it is important for the readership to be aware that this unique group of editors and authors will shortly begin to plan the sixth edition. These efforts and responsibilities are truly labors of love, which have provided us with enormous satisfaction. We all hope that this edition of Hematology: Basic Principles and Practice will not only find its way onto your bookshelf or your computer, but be your constant companion as you navigate the field of modern hematology.

- The Authors -

Key Features

A multidisciplinary approach from a unique team of specialists delivers well-rounded guidance on every topic.
"Red boxes" present the authors' unique personal strategies for diagnosis and treatment.
An intuitively re-designed table of contents makes information easier than ever to find.
Online access allows you to rapidly search the entire contents of the book.
Regular online updates personally overseen by Dr. Hoffman keep you apprised of important new developments.

Premium Features

Updates: Access important new discoveries and clinical guidelines as they arise.
Images: Browse a Library of all book images. Easily select, organize, and download your images into a presentation.
Drugs: Reference drug descriptions, indications, contraindications, and adverse reactions from our industry-leading Gold Standard drug formulary.
Case Studies: Review 100+ interactive case studies, from chief complaint through diagnostic testing to diagnosis and detailed discussion.
Patient Info Sheets: Patient information sheets are included to enable you to provide your patients with detailed information on their conditions.
Web Links: Dozens of additional resources at your fingertips.

New to this edition

Ten cutting-edge new chapters - on cellular biology, haploidentical transplantation, hematologic manifestations of parasitic diseases, and more - keep you completely current.
More than 1,000 vibrant images, all presented in full color for the first time, include a collection of detailed photomicrographs in several chapters selected by a hematopathology image consultant.
An enhanced clinical focus makes actionable information easier to find and apply.
Enhanced coverage of pediatric hematology reflects the supervision of new section editor Helen Heslop, MD, FRCPA, FRACP.

Contents

Part 1 - Molecular And Cellular Basis Of Hematology

Chapter 1 - Anatomy And Physiology Of The Gene
Chapter 2 - Genomic Approaches To The Study Of Hematologic Science
Chapter 3 - Protein Synthesis, Processing, And Trafficking
Chapter 4 - Protein Degradation In Cells
Chapter 5 - Protein Architecture: Relationship Of Form And Function
Chapter 6 - Regulation Of Cellular Response
Chapter 7 - Control Of Cell Division
Chapter 8 - Cell Death
Chapter 9 - Pharmacogenomics And Hematologic Diseases

Part 2 - Immunologic Basis Of Hematology

Chapter 10 - Overview And Compartmentalization Of The Immune System
Chapter 11 - B-Cell Development
Chapter 12 - T-Cell Immunity
Chapter 13 - Natural Killer Cell Immunity
Chapter 14 - Dendritic Cell Biology
Chapter 15 - Regulation Of Activation Of B And T Lymphocytes
Chapter 16 - Cell Adhesion
Chapter 17 - Cell Trafficking And Chemokines
Chapter 18 - Tolerance And Autoimmunity

Part 3 - Biology Of Stem Cells And Disorers Of Hematopoiesis

Chapter 19 - Overview Of Stem Cell Biology
Chapter 20 - Cellular Biology Of Hematopoiesis
Chapter 21 - Transcription Factors In Normal And Malignant Hematopoiesis
Chapter 22 - Nonhematopoietic Stem Cells Originating Within The Bone Marrow
Chapter 23 - Interactions Between Hematopoietic Stem/progenitor Cells And The Bone Marrow: The Biology Of Stem Cell Homing And Mobilization
Chapter 24 - The Humoral Regulation Of Hematopoiesis
Chapter 25 - Biology Of Erythropoiesis, Erythroid Differentiation, And Maturation
Chapter 26 - Granulocytopoiesis And Monocytopoiesis
Chapter 27 - Thrombocytopoiesis
Chapter 28 - Inherited Forms Of Bone Marrow Failure
Chapter 29 - Aplastic Anemia
Chapter 30 - Paroxysmal Nocturnal Hemoglobinuria
Chapter 31 - Acquired Disorders Of Red Cell And White Cell Production
Chapter 32 - Thrombocytopenia Due To Decreased Platelet Production

Part 4 - Red Blood Cells

Chapter 33 - Pathobiology Of The Human Erythrocyte And Its Hemoglobins
Chapter 34 - Approach To Anemia In The Adult And Child
Chapter 35 - Pathology Of Iron Metabolism
Chapter 36 - Disorders Of Iron Metabolism: Iron Deficiency And Iron Overload
Chapter 37 - Anemia Of Chronic Diseases
Chapter 38 - Heme Biosynthesis And Its Disorders: Porphyrias And Sideroblastic Anemias
Chapter 39 - Megaloblastic Anemias
Chapter 40 - Laboratory Diagnosis Of Hemoglobinopathies And Thalassemias
Chapter 41 - Thalassemia Syndromes
Chapter 42 - Pathobiology Of Sickle Cell Disease
Chapter 43 - Sickle Cell Disease—clinical Features And Management
Chapter 44 - Hemoglobin Variants Associated With Hemolytic Anemia, Altered Oxygen Affinity, And Methemoglobinemias
Chapter 45 - Red Blood Cell Enzymopathies
Chapter 46 - Red Blood Cell Membrane Disorders
Chapter 47 - Autoimmune Hemolytic Anemia
Chapter 48 - Extrinsic Nonimmune Hemolytic Anemias

Part 5 - Host Defense And Its Disorders

Chapter 49 - Complement And Immunoglobulin Biology
Chapter 50 - Disorders Of Phagocyte Function And Number
Chapter 51 - Disorders Of Lymphocyte Function
Chapter 52 - Histiocytic Disorders
Chapter 53 - Lysosomal Storage Diseases: Perspectives And Principles
Chapter 54 - Infectious Mononucleosis And Other Epstein–barr Virus-Associated Diseases

Part 6 - Hematologic Malignancies

Chapter 55 - Conventional And Molecular Cytogenetic Basis Of Hematologic Malignancies
Chapter 56 - Pharmacology And Molecular Mechanisms Of Antineoplastic Agents For Hematologic Malignancies
Chapter 57 - Radiation Therapy In The Treatment Of Hematologic Malignancies
Chapter 58 - Clinical Use Of Hematopoietic Growth Factors
Chapter 59 - Pathobiology Of Acute Myeloid Leukemia
Chapter 60 - Clinical Manifestations Of Acute Myeloid Leukemia
Chapter 61 - Therapy For Acute Myeloid Leukemia
Chapter 62 - Acute Myeloid Leukemia In Children
Chapter 63 - Pathobiology Of Acute Lymphoblastic Leukemia
Chapter 64 - Clinical Manifestations Of Acute Lymphoblastic Leukemia
Chapter 65 - Treatment Of Childhood Acute Lymphoblastic Leukemia
Chapter 66 - Acute Lymphocytic Leukemia In Adults
Chapter 67 - Myelodysplastic Syndromes: Biology And Treatment
Chapter 68 - The Polycythemias
Chapter 69 - Chronic Myeloid Leukemia
Chapter 70 - Primary Myelofibrosis
Chapter 71 - Essential Thrombocythemia
Chapter 72 - Eosinophilia, Eosinophil-Associated Diseases, Chronic Eosinophil Leukemia, And The Hypereosinophilic Syndromes
Chapter 73 - Mast Cells And Systemic Mastocytosis
Chapter 74 - Myelodysplastic And Myeloproliferative Syndromes In Children
Chapter 75 - Pathobiology Of Non-Hodgkin Lymphoma
Chapter 76 - Pathobiology Of Hodgkin Lymphoma
Chapter 77 - Hodgkin Lymphoma: Clinical Manifestations, Staging, And Therapy
Chapter 78 - The Pathologic Basis For The Classification Of Non-Hodgkin Lymphomas
Chapter 79 - Clinical Manifestations, Staging, And Treatment Of Indolent Non-Hodgkin Lymphoma
Chapter 80 - Diagnosis And Treatment Of Non-Hodgkin Lymphoma (Aggressive)
Chapter 81 - Malignant Lymphomas In Childhood
Chapter 82 - Radioimmunotherapy For B-Cell Non-Hodgkin Lymphoma
Chapter 83 - Chronic Lymphocytic Leukemia
Chapter 84 - Hairy Cell Leukemia
Chapter 85 - Cutaneous T-Cell Lymphomas
Chapter 86 - Aids-Related Lymphomas
Chapter 87 - Multiple Myeloma
Chapter 88 - Waldenstr�m Macroglobulinemia/lymphoplasmacytic Lymphoma
Chapter 89 - Immunoglobulin Light-Chain Amyloidosis (Primary Amyloidosis)
Chapter 90 - Atypical Immune Lymphoproliferations
Chapter 91 - Clinical Approach To Infections In The Compromised Host
Chapter 92 - Nutritional Support Of Patients With Hematologic Malignancies
Chapter 93 - Psychosocial Aspects Of Hematologic Disorders
Chapter 94 - Pain Management And Antiemetic Therapy In Hematologic Disorders
Chapter 95 - Palliative Care
Chapter 96 - Indwelling Access Devices
Chapter 97 - Late Complications Of Hematologic Diseases And Their Therapies

Part 7 - Transplantation

Chapter 98 - Overview Of Cell- And Immune-Based Therapies
Chapter 99 - Hematopoietic Stem Cell Transplantation For Acquired Nonmalignant Diseases And Myelodysplastic Syndrome
Chapter 100 - Hematopoietic Stem Cell Transplantation For Immune Deficiencies And Genetic Disorders
Chapter 101 - Outcomes Of Allogeneic Hematopoietic Cell Transplantation For Hematologic Malignancies In Adults
Chapter 102 - Autologous Transplantation For Hematologic Malignancies
Chapter 103 - Unrelated Donor Hematopoietic Cell Transplantation
Chapter 104 - Haploidentical Hematopoietic Cell Transplantation
Chapter 105 - Umbilical Cord Blood Transplantation
Chapter 106 - Preparative Regimens For Hematopoietic Cell Transplantation
Chapter 107 - Graft-Versus-Host Disease And Graft-Versus-Leukemia Responses
Chapter 108 - Practical Aspects Of Stem Cell Collection
Chapter 109 - Graft Engineering And Cell Processing
Chapter 110 - Gene Transfer For Hematologic Disorders
Chapter 111 - Experimental Cell Therapy
Chapter 112 - Stem Cells For Tissue Repair
Chapter 113 - Complications After Hematopoietic Cell Transplantation

Part 8 - Hemostasis And Thrombosis

Chapter 114 - Megakaryocyte And Platelet Structure
Chapter 115 - The Molecular Basis Of Platelet Function
Chapter 116 - The Molecular Basis Of Platelet Activation
Chapter 117 - The Blood Vessel Wall
Chapter 118 - Molecular Basis Of Blood Coagulation
Chapter 119 - Molecular And Cellular Basis Of Fibrinolysis
Chapter 120 - Regulatory Mechanisms In Hemostasis: Natural Anticoagulants
Chapter 121 - Clinical Evaluation Of Hemorrhagic Disorders: The Bleeding History And Differential Diagnosis Of Purpura
Chapter 122 - Laboratory Evaluation Of Hemostatic And Thrombotic Disorders
Chapter 123 - Structure, Biology, And Genetics Of Factor Viii
Chapter 124 - Biochemistry Of Factor Ix And Molecular Biology Of Hemophilia B
Chapter 125 - Clinical Aspects And Therapy For Hemophilia
Chapter 126 - Inhibitors In Hemophilia A And B
Chapter 127 - Rare Coagulation Factor Deficiencies
Chapter 128 - Structure, Biology, And Genetics Of Von Willebrand Factor
Chapter 129 - Von Willebrand Disease: Clinical Aspects And Therapy
Chapter 130 - Vitamin K: Metabolism And Disorders
Chapter 131 - Lupus Anticoagulant And Acquired Inhibitors Of Blood Coagulation
Chapter 132 - Disseminated Intravascular Coagulation
Chapter 133 - Disorders Of Coagulation In The Neonate
Chapter 134 - Hypercoagulable States
Chapter 135 - Venous Thromboembolism
Chapter 136 - Arterial Thromboembolism
Chapter 137 - Antithrombotic Drugs
Chapter 138 - Immune Thrombocytopenic Purpura, Neonatal Alloimmune Thrombocytopenia, And Posttransfusion Purpura
Chapter 139 - Thrombotic Thrombocytopenic Purpura And The Hemolytic Uremic Syndrome
Chapter 140 - Thrombocytopenia Due To Platelet Destruction And Hypersplenism
Chapter 141 - Hereditary Disorders Of Platelet Function
Chapter 142 - Acquired Disorders Of Platelet Function

Part 9 - Transfusion Medicine

Chapter 143 - Human Blood Group Antigens And Antibodies
Chapter 144 - Human Platelet Antigens
Chapter 145 - Human Leukocyte Antigen And Human Neutrophil Antigen Systems
Chapter 146 - Principles Of Red Blood Cell Transfusion
Chapter 147 - Principles Of Platelet Transfusion Therapy
Chapter 148 - Principles Of Neutrophil (Granulocyte) Transfusions
Chapter 149 - Transfusion Of Plasma Derivatives: Fresh-Frozen Plasma, Cryoprecipitate, Albumin, And Immunoglobulins
Chapter 150 - Preparation Of Plasma-Derived And Recombinant Human Plasma Proteins
Chapter 151 - Transfusion Therapy For Coagulation Factor Deficiencies
Chapter 152 - Hemapheresis And Cellular Therapy
Chapter 153 - Transfusion Reactions
Chapter 154 - Transfusion-Transmitted Diseases
Chapter 155 - Transfusion Medicine In Hematopoietic Stem Cell And Solid Organ Transplantation

Part 10 - Consultative Hematology

Chapter 156 - Hematologic Manifestations Of Systemic Disease: Liver And Renal Disease
Chapter 157 - Hematologic Manifestations Of Systemic Disease: Infection, Chronic Inflammation, And Cancer
Chapter 158 - Hematologic Manifestations Of Aids
Chapter 159 - Hematologic Aspects Of Parasitic Diseases
Chapter 160 - Hematologic Problems In The Surgical Patient: Bleeding And Thrombosis
Chapter 161 - Hematologic Changes Of Pregnancy
Chapter 162 - Hematologic Manifestations Of Childhood Illness
Chapter 163 - The Spleen And Its Disorders
Chapter 164 - Appendix: Normal Blood Values: Selected Reference Values For Neonatal, Pediatric, And Adult Populations

About the Authors

Ronald Hoffman, MD, Albert A. and Vera G. List Professor of Medicine; Hematology/Oncology Section; Mount Sinai Cancer Institute, Department of Medicine, Cell and Gene Medicine, Mount Sinai School of Medicine New York, New York.
Edward J. Benz Jr., MD, Richard and Susan Smith Professor of Medicine, Professor of Pediatrics, and Professor of Pathology, Harvard Medical School; President and CEO, Dana-Farber Cancer Institute; Director, Dana-Farber/Harvard Cancer Center, Boston, Massachusetts.
Sanford J. Shattil, MD, Professor of Medicine and Chief, Hematology-Oncology Division, University of California San Diego; Adjunct Professor of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California.
Bruce Furie, MD, Professor of Medicine, Harvard Medical School; Chief, Division of Hemostasis and Thrombosis, Beth Israel Deaconess Medical Center, Boston, Massachusetts.
Leslie E. Silberstein, MD, Professor of Pathology, Harvard Medical School; Director, Joint Program in Transfusion Medicine, Children's Hospital Boston, Brigham and Women's Hospital, and Dana-Farber Cancer Institute; Director, Center for Human Cell Therapy, Immune Disease Institute, Boston, Massachusetts.
Philip McGlave, MD, C.J. Watson Land Grant Chair in Medicine; Director, Division of Hematology, Oncology and Transplantation; Deputy Director, Masonic Cancer Center, University of Minnesota, Academic Health Center, Minneapolis, Minnesota.
Helen E. Heslop, MD, Professor of Medicine and Pediatrics, Dan L Duncan Chair, Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital and Texas Children's Hospital, Houston, Texas.

Hematology Image Consultant:

John Anastasi, MD, Associate Professor of Pathology, Assistant Director, Hematopathology, University of Chicago, Pritzker School of Medicine, Chicago, Illinois.

Product Details

Hardcover: 2560 pages
Publisher: Churchill Livingstone; 5 edition (October 30, 2009)
Language: English
ISBN-10: 0443067155
ISBN-13: 978-0443067150
Product Dimensions: 11 x 8.8 x 2.8 inches

List Price: $314.00

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