Zipes Cardiac Electrophysiology: From Cell to Bedside 5th Edition (Expert Consult Series)

In the five years since the fourth edition of this book was published, advances in cardiac electrophysiology have been impressive. A broadening understanding of the fundamental electrophysiologic mechanisms underlying normal and abnormal cardiac excitation and impulse propagation is emerging, thanks in part to leapfrog improvements in technology, from the use of voltage clamping and the Ling Gerard microelectrode, through patch clamping and molecular biology, to optical mapping, computer modeling, and molecular genetics. A wide variety of basic mechanisms of normal and abnormal cardiac excitation, impulse propagation, and arrhythmias have been well described as a result of such improvements. In addition, basic cardiac electrophysiology has contributed to identification of disease loci for currently known mutations in proteins that form sarcolemmal and sub-sarcolemmal ion channels, discoveries that have greatly improved current understanding of the substrate for cardiac arrhythmias in both inherited and acquired diseases. The first part of Cardiac Electrophysiology: From Cell to Bedside addresses all of these issues and offers a conglomerate of comprehensive reviews on modern concepts in basic cardiac electrophysiology. This in-depth background is provided to help the reader integrate knowledge from the molecular to the organ level and to support translation of that knowledge into clinical practice.

The second half of the book focuses on clinical progress, which has been equally remarkable, with continued elucidation of pathophysiologic mechanisms responsible for many arrhythmias, including the different types of atrial fibrillation and many ventricular tachyarrhythmias, as well as new approaches to their management. Development of drugs, devices, and ablation techniques continues to advance at a startling pace. Perhaps no area has progressed as much as research into the genetic underpinning of many arrhythmias, not just those clearly related to ion channel abnormalities such as long and short QT syndromes, catecholaminergic ventricular tachycardia, right ventricular and hypertrophic cardiomyopathies, and Brugada syndrome, but the more common arrhythmias such as atrial fibrillation, ventricular tachycardia, and those related to sudden cardiac death. The growth of new imaging modalities has been breathtaking and has kept pace with the need for better pictures of cardiac anatomy, particularly of the left atrium and pulmonary veins. Advances in recording electrical signals from the heart can be marked by three phases: development of the electrocardiograph, catheter-based intracardiac recordings, and now ECG imaging. The last phase has opened a new era into noninvasive assessment of cardiac activation.

The format of the book continues to evolve as well. The use of color throughout maximizes accessibility of information presented in the figures and diagrams, as well as providing a more attractive appearance overall. In addition, the electronic format facilitates availability for ready reference. As before, the authors of the chapters are the leaders in their areas, and we are pleased that they consider writing for Cardiac Electrophysiology: From Cell to Bedside a happy task. We thank them for their contributions, which continue to make this book an important reference text for basic and clinical scientists, clinicians, and general cardiologists. We strive to craft it as the all-inclusive knowledge source, literally "from cell to bedside," for those interested in heart rhythms. We think it is one of the few books accomplishing that goal with such an authoritative list of experts.

Finally, we thank our wives, Joan Zipes and Paloma Jalife, whose constant support allows us to undertake such endeavors as this, and the people at Elsevier, particularly Natasha Andjelkovic, Janice Gaillard, and Jeff Gunning, for all their help.

In the final analysis, the reader determines the success or failure of a book, and we are pleased that so many of you liked the previous editions and have made this publication an important part of your educational resources. We hope that this edition meets your expectations equally well.

- The Authors -

Key Features

• Integrates the latest scientific understanding of arrhythmias with the newest clinical applications, giving you an informed basis for choosing the right treatment and management options for each patient.
• Synthesizes the knowledge of preeminent authorities in cardiology, physiology, pharmacology, pediatrics, biophysics, pathology, cardiothoracic surgery, and biomedical engineering from around the world, giving you a well-rounded, expert grasp of every issue that affects your patient management.

Website Features

• Consult the book from any computer at home, in your office, or at any practice location.
• Instantly locate the answers to your clinical questions via a simple search query.
• Quickly find out more about any bibliographical citation by linking to its MEDLINE abstract.

Contents 

Introduction: Progress in Antiarrhythmic Therapies 

• Background
• Successful Therapeutics
• Proving Therapeutic Efficacy
• Implementing Successful Therapy
• Conclusions
• References

PART I - Structural and Molecular Bases of Ion Channel Function

• Chapter 1 - Voltage-Gated Sodium Channels and Electrical Excitability of the Heart
• Chapter 2 - Cardiac Calcium Channels
• Chapter 3 - Voltage-Regulated Potassium Channels
• Chapter 4 - Intracellular Signaling and Regulation of Cardiac Ion Channels
• Chapter 5 - Membrane Pumps and Exchangers
• Chapter 6 - Sarcoplasmic Reticulum Ion Channels
• Chapter 7 - Hyperpolarization-Activated, Cyclic Nucleotide–Gated (HCN) Channels: From Genes to Function
• Chapter 8 - Molecular Organization and Regulation of the Cardiac Gap Junction Channel Connexin 43

PART II - Biophysics of Cardiac Ion Channel Function

1. Chapter 9 - Biophysics of Normal and Abnormal Cardiac Sodium Channel function
2. Chapter 10 - Gating of Cardiac Delayed Rectifier Potassium Channels
3. Chapter 11 - Cardiac Stretch–Activated Channels and Mechano-Electric Transduction
4. Chapter 12 - The Sinoatrial Node: Its Complex Structure and Unique Ion Channel Gene Program
5. Chapter 13 - Biophysical Properties of Inwardly Rectifying Potassium Channels
6. Chapter 14 - Biophysical Properties of Gap Junctions

PART III - Intermolecular Interactions and Pharmacology of Cardiac Ion Channels

• Chapter 15 - Developmental Regulation of Cardiac Ion Channels
• Chapter 16 - Pharmacology of the Cardiac Sodium Channel
• Chapter 17 - Pharmacology of L-type and T-type Calcium Channels in the Heart
• Chapter 18 - KCNQ1/KCNE1 Macromolecular Signaling Complex: Channel Microdomains and Human Disease
• Chapter 19 - Drug-Induced Channelopathies
• Chapter 20 - Connexins as Potential Targets for Cardiovascular Pharmacology

PART IV - Cell Biology of Cardiac Impulse Initiation and Propagation

• Chapter 21 - Fibrosis and Fibroblast Infiltration: An Active Structural Substrate for Altered Propagation and Spontaneous Tachyarrhythmias
• Chapter 22 - Biologic Pacing
• Chapter 23 - A New Functional Paradigm for the Heart's Pacemaker: Mutual Entrainment of Intracellular Calcium Clocks and Surface Membrane Ion Channel Clocks
• Chapter 24 - Mechanisms of Atrioventricular Nodal Excitability and Propagation
• Chapter 25 - Intercellular Communication and Impulse Propagation
• Chapter 26 - Cardiac Myofibroblasts and Arrhythmogenesis
• Chapter 27 - Cardiac Alternans as a Pathophysiologic Mechanism of Arrhythmias
• Chapter 28 - Heterogeneous Expression of Repolarizing Potassium Currents in the Mammalian Myocardium
• Chapter 29 - Gap Junction Distribution and Regulation in the Heart

PART V - Models of Cardiac Excitation

• Chapter 30 - Ionic Mechanisms of Ventricular Action Potential Excitation
• Chapter 31 - Theory of Reentry
• Chapter 32 - Nonlinear Dynamics of Excitation and Propagation in Cardiac Muscle
• Chapter 33 - Rotors and Spiral Waves in the Heart
• Chapter 34 - Modeling Cardiac Defibrillation

PART VI - Neural Control of Cardiac Electrical Activity

• Chapter 35 - Adrenergic Signaling and Cardiac Ion Channels
• Chapter 36 - Nerve Sprouting and Cardiac Arrhythmias
• Chapter 37 - Neurocardiac Imaging
• Chapter 38 - Neural Mechanisms Initiating and Maintaining Arrhythmias: Summarizing Data from Animal Models and Human Diseases

PART VII - Arrhythmia Mechanisms

• Chapter 39 - Role of Cardiac and Thoracic Veins in Arrhythmogenesis
• Chapter 40 - Dominant Frequency and the Mechanisms of Maintenance of Atrial Fibrillation
• Chapter 41 - Electrophysiologic Basis of Electrogram Fragmentation in Atrial Fibrillation
• Chapter 42 - Structural Atrial Remodeling Alters the Substrate and Spatiotemporal Organization of Atrial Fibrillation
• Chapter 43 - Molecular Remodeling and Chronic Atrial Fibrillation
• Chapter 44 - Noninvasive Electrocardiographic Imaging: Methodology and Excitation of the Normal Human Heart
• Chapter 45 - Dynamics and Molecular Mechanisms of Ventricular Tachycardia and Fibrillation in Normal Hearts
• Chapter 46 - Mechanisms of Ischemic Ventricular Fibrillation
• Chapter 47 - Insight into Mechanisms of Ventricular Tachycardia from Isolated Wedge Preparations
• Chapter 48 - Mechanisms of Defibrillation

PART VIII - Molecular Genetics and Pharmacogenomics

• Chapter 49 - Single Nucleotide Polymorphisms and Cardiac Arrhythmias
• Chapter 50 - Inheritable Sodium Channel Diseases
• Chapter 51 - Inheritable Potassium Channel Diseases
• Chapter 52 - Inheritable Disease of Intracellular Calcium Regulation
• Chapter 53 - Pharmacogenomics of Cardiac Arrhythmias and Effect on Drug Therapy

PART IX - Supraventricular Arrhythmias: Mechanisms, Features, and Management

• Chapter 54 - Morphologic Correlates of Atrial Arrhythmias
• Chapter 55 - Atrial Flutter
• Chapter 56 - Atrial Fibrillation: Mechanisms, Features, and Management
• Chapter 57 - Atrial Tachycardia
• Chapter 58 - Atrioventricular Reentry and Variants
• Chapter 59 - Electrophysiologic Characteristics of Atrioventricular Nodal Reentrant Tachycardia: Implications for Reentrant Circuits
• Chapter 60 - Atrial Arrhythmias in Congenital Heart Disease

PART X - Ventricular Arrhythmias: Mechanisms, Features, and Management

• Chapter 61 - Ventricular Tachycardia in Patients with Structurally Normal Hearts
• Chapter 62 - Ventricular Tachycardia in Patients with Coronary Artery Disease
• Chapter 63 - Ventricular Tachycardia in Patients with Dilated Cardiomyopathy
• Chapter 64 - Arrhythmogenic Right Ventricular Cardiomyopathies
• Chapter 65 - Ventricular Arrhythmias in Hypertrophic Cardiomyopathy
• Chapter 66 - Ventricular Tachycardia in Patients with Heart Failure
• Chapter 67 - Ventricular Tachycardia in Patients after Surgery for Congenital Heart Disease
• Chapter 68 - The Brugada Syndrome
• Chapter 69 - Long QT and Short QT Syndromes
• Chapter 70 - Catecholaminergic Polymorphic Ventricular Tachycardia
• Chapter 71 - Andersen-Tawil Syndrome
• Chapter 72 - Timothy Syndrome
• Chapter 73 - Idiopathic Ventricular Fibrillation
• Chapter 74 - Drug-Induced Ventricular Tachycardia
• Chapter 75 - Progressive Cardiac Conduction Disease
• Chapter 76 - Sudden Infant Death Syndrome
• Chapter 77 - Sudden Cardiac Death
• Chapter 78 - Arrhythmias in Patients with Neurologic Disorders

PART XI - Electrocardiographic Recognition

• Chapter 79 - Parasystole
• Chapter 80 - Differential Diagnosis for Wide QRS Complex Tachycardia

PART XII - Diagnostic Evaluation

• Chapter 81 - Assessment of the Patient with a Cardiac Arrhythmia
• Chapter 82 - Exercise-Induced Arrhythmias
• Chapter 83 - The Use of Implantable Loop Recorders
• Chapter 84 - High-Resolution Electrocardiography
• Chapter 85 - Head-up Tilt Table Testing
• Chapter 86 - Electrocardiographic and Autonomic Testing of Cardiac Risk
• Chapter 87 - Monophasic Action Potential Recording
• Chapter 88 - T Wave Alternans
• Chapter 89 - Mapping and Imaging
• Chapter 90 - Noninvasive Electrocardiographic Imaging (ECGI): Clinical Applications
• Chapter 91 - Syncope

PART XIII - Arrhythmias in Special Populations

• Chapter 92 - Sudden Cardiac Deaths in Athletes, Including Commotio Cordis
• Chapter 93 - Gender Differences in Arrhythmias
• Chapter 94 - Arrhythmias in Pediatrics
• Chapter 95 - Sleep-Disordered Breathing and Arrhythmias

PART XIV - Pharmacologic Therapy

• Chapter 96 - Standard Antiarrhythmic Drugs
• Chapter 97 - New Antiarrhythmic Drugs and New Concepts for Old Drugs
• Chapter 98 - Impact of Nontraditional Antiarrhythmic Drugs on Sudden Cardiac Death

PART XV - Electrical Therapy

• Chapter 99 - Implantable Cardioverter-Defibrillator: Technical Aspects
• Chapter 100 - Implantable Cardioverter-Defibrillator: Clinical Aspects
• Chapter 101 - Implantable Pacemakers
• Chapter 102 - Cardiac Resynchronization Therapy
• Chapter 103 - Newer Applications of Pacemakers
• Chapter 104 - Lesion-Forming Technologies for Catheter Ablation
• Chapter 105 - Atrial Substrate Ablation in Atrial Fibrillation
• Chapter 106 - Pulmonary Vein Isolation for Atrial Fibrillation
• Chapter 107 - Catheter Ablation of Supraventricular Arrhythmias
• Chapter 108 - Catheter Ablation for Ventricular Tachycardia in Patients with Structural Heart Disease
• Chapter 109 - Catheter Ablation of Ventricular Arrhythmias in Patients without Structural Heart Disease
• Chapter 110 - Catheter Ablation in Pediatric and Congenital Heart Disease Patients

About the Authors

• Douglas P. Zipes, MD, Distinguished Professor; Emeritus Professor of Medicine, Pharmacology, and Toxicology; Emeritus Director, Division of Cardiology and the Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, Indiana; Editor-in-Chief, HeartRhythm.
• José Jalife, MD, Cyrus and Jane Farrehi Professor of Cardiovascular Research; Professor of Internal Medicine; Professor of Molecular and Integrative Physiology, University of Michigan Medical School; Co-Director, University of Michigan Center for Arrhythmia Research, Ann Arbor, Michigan.

Product Details

• Hardcover: 1184 pages
• Publisher: Saunders; 5 edition (May 6, 2009)
• Language: English
• ISBN-10: 1416059733
• ISBN-13: 978-1416059738
• Product Dimensions: 11.1 x 8.7 x 1.6 inches

List Price: $342.00