In the 12 years since publication of the first edition of Clinical Immunology much has changed; as we have increasingly appreciated the nature of the molecular mechanisms underlying inflammatory responses to specific antigens, the discipline has surely become more complex, more interesting and more demanding of its practitioners. Acquired immunity, the specialized development of vertebrate host defenses, was for many decades the primary focus of attention. Recently, however, we have witnessed an explosion of information relating to the phylogenetically older systems of innate immunity, which has concurrently enlarged the purview of clinical immunology. In addition to those classical diseases of the acquired immune system, clinical immunologists today are increasingly interested in a range of inflammatory diseases where rearranged antigen-specific receptors have not been demonstrated or may not be involved. Rather than specific antigen receptors, these disorders are mediated by pathogen-recognition systems such as Toll-like receptors on NK lymphocytes and phagocytic cells. These trigger inflammatory effector processes that were later adopted by the acquired immune system, such as elaboration of soluble inflammatory mediators (cytokines and chemokines), complement activation, phagolysosome-mediated pathogen elimination and programmed cell death.
The third edition reflects this improved understanding with increased attention to processes and diseases of inflammation and a broadly defined view of host defenses. We trust that this has been accomplished while retaining a principal focus on those many diseases at the core of clinical immunology arising from deficiency or aberration of functions of acquired immunity.
Two changes will be immediately apparent to readers familiar with the previous editions. The third edition is, we believe, much enhanced by production in full color throughout. Clinical case photos are increased and are presented more usefully in the context of text discussion. Similarly line drawings are not only more attractive, but utilize color effectively to enrich their information content. The second obvious change is that we have chosen to publish the book in a single (albeit large) volume rather than in the previous two-volume format. We believe that by editing to reduce redundancy, judicious referencing (with an emphasis on recent reviews) and tightening presentation, the third edition is consequently more “user friendly,” eliminating the necessity to consult more than a single volume, while not compromising overall content quality or quantity. There is also a third important change that is not immediately obvious, but which will considerably enhance the long-term usefulness of the book. This third change is the intent to provide quarterly electronic updates to registered purchasers relating to key advances in clinical immunology since the publication of this edition. We are confident that such updates will help to keep the book fresh as our field advances.
The process of editing a book of this size represents the combined efforts of many individuals in addition to the editors and authors. Two persons, however, warrant special thanks for their essential roles in shepherding this work to its conclusion: Martin Mellor and Randell Baker, whose efforts on behalf of the editors, authors and, finally, the readers, is gratefully acknowledged.
We trust that the book continues to find a useful place on the desks and book shelves of clinical immunologists of many stripes—from the specialized practitioner of clinical immunology (either generalized or organ-system oriented), to the generalist or organ-based specialist who is interested in state-of-the-art approaches to management of inflammatory conditions, and to the fundamental immunologist interested in mechanisms of immunologic diseases. Finally, upon reviewing this comprehensive text on clinical immunology, which delves into the many and increasingly diverse areas of immune system related diseases, the editors hope that this recording of the expanse and depth of knowledge in our specialty will impart a sense of pride and possession to those clinicians and researchers who call themselves clinical immunologists.
Robert R. Rich, Thomas A. Fleisher, William T. Shearer, Harry W. Schroeder Jr., Anthony J. Frew, Cornelia M. Weyand
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Contents
Part 1 - Fundamental Principles of the Immune Response
- Chapter 1 - The human immune response
- Chapter 2 - Organization of the immune system
- Chapter 3 - Innate immunity
- Chapter 4 - Antigen receptor genes, gene products, and co-receptors
- Chapter 5 - The major histocompatibility complex
- Chapter 6 - Antigens and antigen processing
- Chapter 7 - Antigen-presenting cells and antigen presentation
- Chapter 8 - B-cell development and differentiation
- Chapter 9 - T-cell development
- Chapter 10 - Cytokines and cytokine receptors
- Chapter 11 - Chemokines and chemokine receptors
- Chapter 12 - Lymphocyte adhesion and trafficking
- Chapter 13 - T-cell activation and tolerance
- Chapter 14 - Programmed cell death in lymphocytes
Part 2 - Host Defense Mechanisms and Inflammation
- Chapter 15 - Immunoglobulin function
- Chapter 16 - Regulatory T cells
- Chapter 17 - Helper T-cell subsets and control of the inflammatory response
- Chapter 18 - Cytotoxic lymphocyte function and natural killer cells
- Chapter 19 - Host defenses at mucosal surfaces
- Chapter 20 - Complement and complement deficiencies
- Chapter 21 - Phagocyte deficiencies
- Chapter 22 - Mast cells, basophils and mastocytosis
- Chapter 23 - Eosinophils and eosinophilia
Part 3 - Infection and Immunity
- Chapter 24 - Immune responses to extracellular bacteria
- Chapter 25 - Immune responses to intracellular bacteria
- Chapter 26 - Immune responses to spirochetes
- Chapter 27 - Immune responses to viruses
- Chapter 28 - Immune responses to protozoans
- Chapter 29 - Immune responses to helminths
Part 4 - Immunologic Deficiencies
- Chapter 30 - Evaluation of the immunodeficient patient
- Chapter 31 - Infections in the immunocompromised host
- Chapter 32 - Development of the fetal and neonatal immune system
- Chapter 33 - Aging and the immune system
- Chapter 34 - Primary antibody deficiencies
- Chapter 35 - Primary T-cell immunodeficiencies
- Chapter 36 - Inherited disorders of IFN-γ-, IFN-α/β-, and NF-κB-mediated immunity
- Chapter 37 - HIV infection and acquired immunodeficiency syndrome
- Chapter 38 - Immunodeficiency due to congenital, metabolic, infectious, surgical, and environmental factors
Part 5 - Allergic Diseases
- Chapter 39 - Pathogenesis of asthma
- Chapter 40 - Management of the asthmatic patient
- Chapter 41 - Rhinitis and sinusitus
- Chapter 42 - Urticaria, angioedema, and anaphylaxis
- Chapter 43 - Allergic reactions to stinging and biting insects
- Chapter 44 - Atopic and contact dermatitis
- Chapter 45 - Food allergy
- Chapter 46 - Eosinophil-associated gastrointestinal disorders (EGID)
- Chapter 47 - Allergic disorders of the eye
- Chapter 48 - Drug hypersensitivity
- Chapter 49 - Occupational and environmental allergic disorders
Part 6 - Systemic Immune Diseases
- Chapter 50 - Mechanisms of autoimmunity
- Chapter 51 - Systemic lupus erythematosus
- Chapter 52 - Rheumatoid arthritis
- Chapter 53 - Juvenile idiopathic arthritis
- Chapter 54 - Sjogren's syndrome
- Chapter 55 - Systemic sclerosis
- Chapter 56 - Inflammatory muscle diseases
- Chapter 57 - Spondyloarthritis
- Chapter 58 - Small- and medium-vessel primary vasculitis
- Chapter 59 - Large-vessel vasculitides
- Chapter 60 - Autoinflammatory fever syndromes
- Chapter 61 - Antiphospholipid syndrome
Part 7 - Organ Specific Inflammatory Disease
- Chapter 62 - Immunohematologic disorders
- Chapter 63 - Bullous diseases of the skin and mucous membranes
- Chapter 64 - Myasthenia gravis
- Chapter 65 - Multiple sclerosis
- Chapter 66 - Autoimmune peripheral neuropathies
- Chapter 67 - Immunologic renal diseases
- Chapter 68 - Inflammation and atherothrombosis
- Chapter 69 - Autoimmune thyroid diseases
- Chapter 70 - Diabetes and related autoimmune diseases
- Chapter 71 - Immunologic lung diseases
- Chapter 72 - Sarcoidosis
- Chapter 73 - Immunologic ocular disease
- Chapter 74 - Immunologic disease of the gastrointestinal tract
- Chapter 75 - Inflammatory hepatobiliary cirrhosis
Part 8 - Neoplasia and the Immune System
- Chapter 76 - Lymphoid leukemias
- Chapter 77 - Lymphomas including Hodgkin lymphoma
- Chapter 78 - Monoclonal gammopathies
- Chapter 79 - Tumor immunology and immunotherapy
Part 9 - Transplantation
- Chapter 80 - Concepts and challenges in transplantation: rejection, immunosuppression and tolerance
- Chapter 81 - Challenges and potentials of xenotransplantation
- Chapter 82 - Hematopoietic stem cell transplantation for malignant diseases
- Chapter 83 - Stem cell transplantation and immune reconstitution in immunodeficiency
- Chapter 84 - Thymic reconstitution
Part 10 - Prevention and Therapy of Immunologic Diseases
- Chapter 85 - Immunoglobulin therapy: replacement and immunomodulation
- Chapter 86 - Gene transfer therapy of immunologic diseases
- Chapter 87 - Glucocorticoids
- Chapter 88 - Nonsteroidal anti-inflammatory drugs
- Chapter 89 - Antihistamines
- Chapter 90 - Immunomodulating pharmaceuticals
- Chapter 91 - Protein kinase antagonists as therapeutic agents for immunological and inflammatory disorders
- Chapter 92 - Vaccines
- Chapter 93 - Immunotherapy of allergic disease
- Chapter 94 - Cytokine therapy
- Chapter 95 - Monoclonal antibodies and fusion proteins
Part 11 - Diagnostic Immunology
- Chapter 96 - Assessment of proteins of the immune system
- Chapter 97 - Flow cytometry
- Chapter 98 - Assessment of functional immune responses
- Chapter 99 - Assessment of neutrophil function
- Chapter 100 - Assessment of human allergic diseases
- Chapter 101 - Molecular methods
APPENDICES
- Appendix: 1: Selected CD molecules and their characteristics
- Appendix: 2: Laboratory reference values
- Appendix: 3: Chemokines
- Appendix 4: Cytokines
Product Details
- Hardcover: 1616 pages
- Publisher: Mosby; 3 edition (April 15, 2008)
- Language: English
- ISBN-10: 0323044042
- ISBN-13: 978-0323044042
- Product Dimensions: 10.3 x 8.2 x 2.6 inches
List Price: $435.00