The fourth edition of The Breast has evolved into a comprehensive text that is highly readable for all medical researchers and clinicians. This tome reviews the basic tenets essential for diagnosis and therapy of the various benign and malignant disorders of the breast. The Editors have sought to develop the proper address of many recognized abnormalities presenting in the diagnosis and therapy of metabolic, physiologic, and neoplastic derangements of the organ. When we compare this edition with the first, second, and third editions, we consider the present text to be even more thorough, inclusive, and relevant to scientific and clinical achievements.
It is our considered opinion that this new edition provides the requirements necessary for young clinicians and scientists to acquire fundamental knowledge of basic, clinical, and laboratory concepts and techniques that will complement their oncology training. Integration of these principles with advancements in technologic, molecular, cellular, and biologic sciences represents the 21st century definition of each specialty involved with the care of breast disease. However, the ultimate measure of professional skill and effectiveness expected of us as clinicians in the management of breast diseases will be the quality that this text brings to bear on patient outcomes, as well as emotional and physical morbidity.
The fourth edition is not intended to replace standard textbooks of surgery, medicine, or biology, nor is this edition considered an encyclopedic recitation of the myriad of pathologic permutations that exist with various disorders of this organ site. The fourth edition of The Breast, however, should coexist with other major medical and surgical reference books. Each chapter is selectively organized and supported with notations of carefully selected journal articles, monographs, or chapters within major reference texts that the contributors of these specific subjects consider a valuable resource. Thus, this work represents a distillation of the herald contributions of innumerable physicians, physiologists, anatomists, geneticists, clinical scientists, and noted health-related workers who have devoted their careers and research to the management of various disorders of the breast.
The fourth edition comprises 21 sections and 95 chapters, with at least 30% additional and/or revised information when compared with the third edition. The opening section documents the historical aspects of breast disease, incorporating the major scientific contributions of investigators and surgeons of the 19th and 20th centuries. The sections that follow include pertinent physiology, anatomy, pathology, genetics, molecular biology, pharmacokinetics, surgery, radiation biology, medical oncology, and biostatistics. Throughout the fourth edition, authors and coauthors have supplemented the text with supportive history of the evolution and chronology of therapeutic principles. In addition, special sections are dedicated to the management of unusual and advanced presentations of the disease.
Additional chapters provide new approaches to the management of breast pain and the risk for carcinoma of the breast following hormonal replacement therapy; a chapter is included that defines patterns of recurrence. The evolution of precise staging evident with lymphatic mapping and sentinel lymph node biopsy has been addressed in depth and provides a new level of precise documentation of technique and outcomes as a consequence of the international experience with the technique since the completion of the second edition. The authors have also incorporated new approaches for gene therapy and counseling for genetic mutations, angiogenesis, immunology, and the evolving role for the immunotherapy of breast cancer. Furthermore, applications of nutritional management and evolving psychologic principles are incorporated in the text. Two chapters, again, are dedicated to addressing legal implications that relate to the management of breast disease. An additional chapter documents the nationwide resources available to both patients and practitioners. Chapters are also dedicated in this edition to covering the psychologic considerations of breast disease and its implications, which affect the patient, spouse, and family members.
With the evolution of this comprehensive reference, overlap will continue to exist among several chapters as a consequence of the dynamic interplay and expectations of medical and surgical practitioners involved with the diagnostic and therapeutic management of the cancer patient. However, the Editors have made every effort to minimize repetitious remarks and dedicated comments except where controversial or “state-of-the art” issues for management exist.
A salient attribute of the text includes the integration of basic science with translational research to emphasize efforts at transfer of knowledge from the bench laboratory to the bedside and the clinic. Only with evolving applications of phase II and phase III trials can the clinician objectively assess the therapeutic value of evolving technical and therapeutic management strategies. These translational research objectives will continue to evaluate promising chemotherapeutics, immunologic agents, inhibitors of angiogenesis, and additional molecularly engineered products that show promise in inhibiting neoplastic progression in this organ.
As previously noted, the authors are hopeful that the fourth edition of The Breast has achieved its developmental and scientific goals for assimilating and collating contemporary basic and clinical scientific data to provide clinicians and researchers with multidisciplinary principles used in practice for the treatment of diseases of the breast. The Editors gratefully acknowledge the opportunity provided by the immense challenge that has been entrusted to us by the publisher and are, again, hopeful that our diligence to this task has been properly served.
Key Features
- Features multidisciplinary advice from experts in surgery, radiation and medical oncology, pathology, molecular biology, pharmacokinetics, and genetics for a well-rounded perspective to enhance patient outcomes.
- Includes more than 1,500 figures and tables that offer high quality depictions of surgery and treatment procedures.
- Offers step-by-step guidance through both text and clinical boxes that makes the material relevant to everyday practice.
- Provides cross-referencing between chapters, as well as references to carefully selected journal articles, that makes further research easier.
Website Features
- Consult the book from any computer at home, in your office, or at any practice location.
- Instantly locate the answers to your clinical questions via a simple search query.
- Quickly find out more about any bibliographical citation by linking to its MEDLINE abstract.
New to this edition
- Features online access to the full text, downloadable images from the book, and more, at expertconsult.com.
- Uses a new full-color design to highlight key areas of the text and help you focus on important concepts.
- Presents updated coverage including an expanded section on pathology...and new chapters on granular cell tumors, targeted therapies, integration of radiotherapy and chemotherapy to keep you current.
- Includes revised chapters on the psychosocial consequences of breast cancer, lifestyle interventions for breast cancer patients, and patient and family resources that equip you to offer complete and compassionate care.
- Provides additional information on genetics to keep you up to date with the latest genetic discoveries linked to breast cancer and breast diseases.
- Features the work of many new contributors who provide the latest and freshest perspectives.
Contents
Volume One
Section I - History of the Therapy of Breast Cancer
- Chapter 1 - History of the Therapy of Breast Cancer
Section II - Anatomy and Physiology of the Normal and Lactating Breast
- Chapter 2 - Anatomy of the Breast, Axilla, Chest Wall, and Related Metastatic Sites
- Chapter 3 - Breast Physiology: Normal and Abnormal Development and Function
- Chapter 4 - Discharges and Secretions of the Nipple
Section III - Benign and Premalignant Lesions
- Chapter 5 - Etiology and Management of Benign Breast Disease
- Chapter 6A - Subareolar Breast Abscess: The Penultimate Stage of the Mammary Duct-associated Inflammatory Disease Sequence
- Chapter 6B - Clinical Management of Mastitis and Breast Abscess and Idiopathic Granulomatous Mastitis
- Chapter 7 - Gynecomastia
- Chapter 8 - Benign, High-Risk, and Premalignant Lesions of the Breast
- Chapter 9 - Congenital and Acquired Disturbances of Breast Development and Growth
Section IV - Pathology of Malignant Lesions
- Chapter 10 - In Situ Carcinomas of the Breast: Ductal Carcinoma in Situ and Lobular Carcinoma in Situ
- Chapter 11 - Infiltrating Carcinomas of the Breast: Not One Disease
- Chapter 12 - Extent and Multicentricity of in Situ and Invasive Carcinoma
- Chapter 13 - Mesenchymal Neoplasms of the Breast
- Chapter 14 - Paget's Disease of the Breast
- Chapter 15 - Primary and Secondary Dermatologic Disorders of the Breast
- Chapter 16 - Digital Automation of Breast Biomarker Immunocytochemistry
- Chapter 17 - Breast Lymphoma
- Chapter 18 - Breast Implants and Related Methods of Breast-Modifying Surgery
Section V - Natural History, Epidemiology, Genetics, and Syndromes of Breast Cancer
- Chapter 19 - Epidemiology of Breast Cancer
- Chapter 20 - Primary Prevention of Breast Cancer
- Chapter 21 - Breast Cancer Genetics: Syndromes, Genes, Pathology, Counseling, Testing, and Treatment
- Chapter 22 - Patterns of Recurrence in Breast Cancer
Section VI - Staging of Breast Cancer
- Chapter 23 - Assessment and Designation of Breast Cancer Stage
Section VII - Prognostic Factors for Breast Cancer
- chapter 24 - Clinically Established Prognostic Factors in Breast Cancer
- chapter 25 - Investigational Molecular Prognostic Factors for Breast Carcinoma
- chapter 26 - Risk Factors for Breast Carcinoma in Women with Proliferative Breast Disease
- chapter 27 - Steroid Receptors in Breast Cancer
Section VIII - Molecular Biology of Breast Carcinogenesis
- Chapter 28 - Molecular Oncology of Breast Cancer
- Chapter 29 - Stem Cells, the Breast, and Breast Cancer
- Chapter 30 - Concepts and Mechanisms of Breast Cancer Metastasis
- Chapter 31 - Gene Therapy for Breast Cancer
- Chapter 32 - Angiogenesis in Breast Cancer
- Chapter 33 - Immune Recognition of Breast Cancer
- Chapter 34 - Immunology and the Role of Immunotherapy in Breast Cancer: Human Clinical Trials
Section IX - Screening and Diagnosis of Breast Disease
- Chapter 35 - Examination Techniques: Roles of the Physician and Patient in Evaluating Breast Disease
- Chapter 36 - Breast Imaging
- Chapter 37 - Interval Breast Cancer: Clinical, Epidemiologic, and Biologic Features
- Chapter 38 - Stereotactic Breast Biopsy
- Chapter 39 - Cytopathology of the Breast
- Chapter 40 - Breast Ductoscopy
Section X - Clinical Trials: Biostatistical Applications
- Chapter 41 - Design and Conduct of Clinical Trials for Breast Cancer
Volume Two
Section XI - Surgery for Benign and Malignant Diseases of the Breast
- Chapter 42 - Evolution of the Surgical Management of Breast Cancer
- Chapter 43 - Indications and Techniques for Biopsy
- Chapter 44 - General Principles of Mastectomy: Evaluation and Therapeutic Options
- Chapter 45 - Halsted Radical Mastectomy
- Chapter 46 - Modified Radical Mastectomy and Total (Simple) Mastectomy
- Chapter 47 - Breast Conservation Therapy for Invasive Breast Cancer
Section XII - Breast Reconstruction
- Chapter 48 - Breast Reconstruction following Mastectomy
- Chapter 49 - Macromastia and Reduction Mammaplasty
Section XIII - Complications of Breast Surgery
- Chapter 50 - Wound Care and Complications of Mastectomy
- Chapter 51 - Lymphedema in the Postmastectomy Patient: Pathophysiology, Prevention, and Management
Section XIV - Current Concepts and Management of Early Breast Carcinoma (Tis, Tmic, T1)
- Chapter 52 - Biology and Management of Lobular Carcinoma in Situ of the Breast (Lobular Neoplasia)
- Chapter 53 - Ductal Carcinoma in Situ: Treatment Controversies and Oncoplastic Surgery
- Chapter 54 - Therapeutic Value of Axillary Node Dissection and Selective Management of the Axilla in Small Breast Cancers
- Chapter 55 - Lymphatic Mapping and Sentinel Lymphadenectomy for Breast Cancer
- Chapter 56 - Detection and Significance of Axillary Lymph Node Micrometastases
- Chapter 57 - Intraoperative Evaluation of Surgical Margins in Breast-Conserving Therapy
- Chapter 58 - Surgical Management of Early Breast Cancer
- Chapter 59 - Percutaneous Ablation: Minimally Invasive Techniques in Breast Cancer Therapy
Section XV - Radiation Therapy for Stages 0, I, and II Breast Cancer
- Chapter 60 - Radiotherapy Techniques
- Chapter 61 - Radiation Therapy for Locally Advanced Disease
- Chapter 62 - Radiotherapy and Ductal Carcinoma in Situ
- Chapter 63 - Radiotherapy and Regional Nodes
- Chapter 64 - Postmastectomy Radiotherapy
- Chapter 65 - Breast-Conserving Therapy for Invasive Breast Cancers
- Chapter 66 - Accelerated Partial Breast Irradiation
- Chapter 67 - Radiation Complications and Their Management
Section XVI - Adjuvant Systemic Modalities for Therapy of Stages I and II Breast Cancer
- Chapter 68 - Adjuvant Chemotherapy for Early-Stage Breast Cancer
Section XVII - Management of Advanced Local and Regional Disease
- Chapter 69 - Surgical Procedures for Advanced Local and Regional Malignancies of the Breast
- Chapter 70 - Solitary Metastases
- Chapter 71 - Locoregional Recurrence after Mastectomy
- Chapter 72 - Locally Advanced Breast Cancer
Section XVIII - Management of Systemic Disease
- Chapter 73 - Detection and Clinical Implications of Occult Systemic Micrometastatic Breast Cancer
- Chapter 74 - Local Therapy for the Intact Breast Primary in the Presence of Metastatic Disease
- Chapter 75 - Management of Bone Metastases in Breast Cancer
- Chapter 76 - Chemotherapy for Metastatic Breast Cancer
- Chapter 77 - Endocrine Therapy for Breast Cancer
- Chapter 78 - Diagnosis and Management of Pleural Metastases in Breast Cancer
- Chapter 79 - Management of Central Nervous System Metastases in Breast Cancer
- Chapter 80 - Management of Pericardial Metastases in Breast Cancer
Section XIX - Special Presentations of Breast Cancer
- Chapter 81 - Bilateral Breast Cancer
- Chapter 82 - Cancer of the Male Breast
- Chapter 83 - Local Recurrence, the Augmented Breast, and the Contralateral Breast
- Chapter 84 - Carcinoma of the Breast in Pregnancy and Lactation
- Chapter 85 - Unknown Primary Presenting with Axillary Lymphadenopathy
- Chapter 86 - Clinical Management of the Patient at Increased or High Risk
- Chapter 87 - Inflammatory Breast Cancer
Section XX - Follow-Up Care and Rehabilitation of the Breast Cancer Patient
- Chapter 88 - General Considerations for Follow-Up
- Chapter 89 - Management of Menopause in the Breast Cancer Patient
- Chapter 90 - Rehabilitation
- Chapter 91 - Psychosocial Consequences and Lifestyle Interventions
- Chapter 92 - Patient and Family Resources
Section XXI - Medical and Legal Issues Specific to the Care of Breast Cancer
- Chapter 93 - Medical-Legal Aspects of Breast Care
- Chapter 94 - Delayed Diagnosis of Symptomatic Breast Cancer
About the Authors
- Kirby I. Bland, MD, Fay Fletcher Kerner Professor and Chair, Department of Surgery, Deputy Director, UAB Comprehensive Cancer Center, University of Alabama School of Medicine, Birmingham, Alabama.
- Edward M. Copeland III, MD, Distinguished Professor, Department of Surgery, University of Florida College of Medicine, Gainesville, Florida.
Book Review
There are clinical textbooks for each medical specialty, and there are clinical textbooks that transcend specialties. The former are useful, but the latter are invaluable. Since its inception in 1991, The Breast: Comprehensive Management of Benign and Malignant Disorders has become the undisputed reference for anatomic, pathologic, genetic, immunologic, medical, and surgical aspects of neoplastic and non-neoplastic breast disease. This comprehensive text seamlessly integrates multidisciplinary diagnosis and management in a logical sequence of clearly written and well-referenced chapters from experts in the field.
Drs. Bland and Copeland, both internationally respected experts in breast disease, created The Breast as a comprehensive, readable presentation of the basic principles necessary for the diagnosis and treatment of various benign and malignant breast diseases. Their admirable success in part reflects the overall organization of the two-volume text: 95 chapters divided into 21 sections. Sections I through XIII cover breast anatomy, benign and premalignant lesions, pathology of malignancy, epidemiology, prognostic factors, molecular biology, screening and diagnosis, and surgical management. The remaining sections offer detailed, objective management guidelines for each stage of breast cancer, including surgical, radiologic, and systemic approaches. In addition, Volume Two includes genetics-based risk assessment; approaches to special presentations of breast cancer, such as breast cancer in pregnancy and axillary involvement without a known primary lesion; and an interesting discussion of medical-legal issues in breast cancer. Chapters are supported by carefully chosen treatment diagrams, figures, and tables; cross-referencing between chapters further increases ease of use.
My specialty is surgical oncology with a focus on melanoma, but an earlier edition of The Breast sits on my shelf and I reach for it when I need an authoritative, reliable reference on breast disease. I have used it to review the lymphatic physiology of the breast, the multidisciplinary management of systemic disease, the implications of recurrence in the reconstructed breast, and tumor markers of breast cancer, among other subjects. This text is an essential resource for all clinicians.
Improved treatments have reduced the mortality of breast cancer in the United States; it is now only the second highest cause of cancer deaths in women. However, every few minutes there is another diagnosis of breast cancer, and breast cancer remains the most frequent cancer in women, striking one of every eight females. These statistics mean that most clinicians will see patients with risk factors, signs, or symptoms of breast problems, and they must be prepared to give advice regarding the many different paradigms for management of benign or malignant breast disease. No diagnosis causes more emotion and fear in a woman than breast cancer, and no topic stimulates more multidisciplinary controversy than its optimum management. For these reasons, nonspecialists as well as specialists must maintain a high index of suspicion for possible malignancy and a high level of knowledge about breast disease. The fourth edition of The Breast will allow them to do so.
-- By Donald L. Morton, MD, FACS, John Wayne Cancer Institute at Saint John's Health Center.
Product Details
- Hardcover: 1712 pages
- Publisher: Saunders; 4 edition (July 31, 2009)
- Language: English
- ISBN-10: 1416052216
- ISBN-13: 978-1416052210
- Product Dimensions: 11.7 x 9.3 x 4.1 inches
List Price: $395.00