Jaffe: Hematopathology (Expert Consult Series)

Hematopathology is a discipline in which the traditional methods of clinical and morphologic analysis are interwoven with newer, biologically based studies to achieve an accurate diagnosis. Studies of hematologic malignancies have been at the forefront in applying the principles of basic research to the understanding of human disease. All cancers are increasingly recognized as genetic diseases, with precise genetic alterations often defining entities. Advances in immunologic and molecular genetic technology have rapidly migrated to the clinical laboratory, where they play a role in routine diagnosis. The authors and editors embrace this new technology. Indeed, it is only possible to understand the histopathologic spectrum of disease if one has an appreciation for the underlying biology and the varied functions of the cells encountered in lymph nodes and bone marrow. The reader will find that the discussion of each disease includes both a description of morphologic features and relevant immunophenotypic, genetic, and clinical features. These data inform our understanding of disease pathogenesis, and provide valuable and often critical adjuncts to diagnosis. The goal is to provide concise, up-to-date, and practical information that is easy for the reader to access.
Pathologic diagnosis cannot occur in a vacuum, and the pathologist must understand the key clinical characteristics of the diseases being considered in the differential. Therefore, discussion of each disease includes a description of expected clinical features at the time of diagnosis, including signs, symptoms, and relevant staging procedures. Chapters dealing with neoplastic disorders incorporate a discussion of patterns of spread, relapse, and prognostic factors.
We hope that this book will be of value to hematologists and oncologists, in addition to pathologists. It is increasingly important that clinicians be aware of basic principles of hematopathology diagnosis; hematologists and hematopathologists must work as a team to achieve the correct diagnosis. Just as the pathologist must use clinical data to make an accurate diagnosis, the clinician should have sufficient knowledge of diagnostic principles to appreciate when the pathological diagnosis just doesn't quite fit.
The use of correct technique is critical in producing a lymph node or bone marrow biopsy specimen that is suitable for accurate diagnosis. Many diagnostic errors stem from poor technique related to fixation, processing, cutting, or staining. The first section of this book deals with technical aspects in the processing of lymph node and bone marrow specimens. While the use of fine needle aspiration for primary diagnosis is controversial, it is critical to be aware of how this diagnostic tool can be used, as well as of its limitations. Thus, a chapter is devoted to this topic. Finally, several chapters deal with the implementation of techniques used in hematopathologic diagnosis, including immunohistochemistry, flow cytometry, molecular genetic techniques in diagnosis, and both classical and interphase cytogenetics.
A discussion of hematologic malignancies derived from myeloid, lymphoid, histiocytic, and dendritic cells represents a major feature of this book. Equally relevant to the diagnostic pathologist is an appreciation of the spectrum of reactive and inflammatory lesions of hematolymphoid tissues occurring in immunocompetent patients as well as those with disimmunity. Thus, the reader will find a discussion of reactive lymphadenopathies and primary and iatrogenic immunodeficiency disorders. Further chapters deal with the bone marrow response to inflammatory, infectious, and metabolic diseases, the findings in a number of inherited and congenital disorders that affect hematopoiesis, and the impact of therapy on bone marrow morphology. Finally, we also include some non-hematopoietic lesions that may be encountered in lymph nodes or bone marrow that are important in differential diagnosis.
The reader will find that most of the chapters deal with a specific disease entity or a group of related diseases. Several key tables have been included in each chapter to facilitate use and access to key facts. These include: major diagnostic features, differential diagnosis, and pearls and pitfalls. The book is generously illustrated, and the consistent use of color photography throughout should make it easy to appreciate key diagnostic features.
The editors appreciate that the reader needs to have access to key source material and that a richly referenced book provides important information for those who wish to delve further into the topic. The scientific literature is voluminous, and we feel it is important to include older historical references as well as the most recent scientific data. Because we increasingly access the medical literature through electronic media, we and the publishers have elected to include the references only on the Expert Consult website for the book. We believe that this minor inconvenience will be outweighed by electronic access to the PubMed links instantaneously, with of course the ability to further research the topic and identify new key references as they appear.
This book has had a long gestation, with the first discussions beginning more than 10 years ago. The editors envisioned a book that would be both practical and accessible but also contain the scientific insights that we feel are critical to understanding pathogenesis and pathophysiology of hematolymphoid disorders. Starts and stops occurred along the way, as both editors and authors were distracted by new scientific developments and the need to create an updated World Health Organization classification of neoplasms of hematopoietic and lymphoid tissues. We believe that the product has met our expectations for an up-to-date and comprehensive text on diagnostic hematopathology, and we hope it meets yours as well. We thank the many authors who both adhered to deadlines and responded to our aims for the book. We hope this book will prove to be a constant and valued resource for pathologists and clinicians dealing with hematologic diseases, and that it will ultimately benefit the patients and their families.
Elaine S. Jaffe, Nancy Lee Harris, James W. Vardiman, Elias Campo, Daniel A. Arber.

Key Features
  • Overcome the toughest diagnostic challenges with authoritative guidance from the world's leading experts.
  • Make optimal use of the newest diagnostic techniques, including molecular, immunohistochemical, and genetic studies.
  • Compare specimens of more than 1,100 high-quality color images to confirm or challenge your diagnostic interpretations.

Website Features
  • Consult the book from any computer at home, in your office, or at any practice location.
  • Instantly locate the answers to your clinical questions via a simple search query.
  • Quickly find out more about any bibliographical citation by linking to its MEDLINE abstract.
  • Images: Browse a Library of all book images. Easily select, organize, and download your images into a presentation.

Part I - Technical Aspects
  • Chapter 1 - Processing of the Lymph Node Biopsy Specimen
  • Chapter 2 - Fine-Needle Aspiration of Lymph Nodes
  • Chapter 3 - Collection, Processing, and Examination of Bone Marrow Specimens
  • Chapter 4 - Immunohistochemistry for the Hematopathology Laboratory
  • Chapter 5 - Flow Cytometry
  • Chapter 6 - Molecular Diagnosis in Hematopathology
  • Chapter 7 - Cytogenetic Analysis and Related Techniques in Hematopathology
Part II - Normal and Reactive Conditions of Hematopoietic Tissues
  • Chapter 8 - Normal Lymphoid Organs and Tissues
  • Chapter 9 - The Reactive Lymphadenopathies
  • Chapter 10 - The Normal Bone Marrow
  • Chapter 11 - Evaluation of Anemia, Leukopenia, and Thrombocytopenia
  • Chapter 12 - Bone Marrow Findings in Inflammatory, Infectious, and Metabolic Disorders
Part III - Lymphoid Neoplasms
  • Chapter 13 - Principles of Classification of Lymphoid Neoplasms
Section 1 - Mature B-Cell Neoplasms
  • Chapter 14 - Mature B-Cell Neoplasms
  • Chapter 15 - Hairy Cell Leukemia
  • Chapter 16 - Splenic Marginal Zone Lymphoma
  • Chapter 17 - Follicular Lymphoma
  • Chapter 18 - Extranodal Marginal Zone Lymphoma
  • Chapter 19 - Primary Cutaneous B-Cell Lymphoma
  • Chapter 20 - Nodal Marginal Zone Lymphoma
  • Chapter 21 - Mantle Cell Lymphoma
  • Chapter 22 - Diffuse Large B-Cell Lymphoma
  • Chapter 23 - Lymphomatoid Granulomatosis
  • Chapter 24 - Burkitt's Lymphoma
  • Chapter 25 - Plasma Cell Neoplasms
  • Chapter 26 - Nodular Lymphocyte-Predominant Type of Hodgkin's Lymphoma
  • Chapter 27 - Classical Hodgkin's Lymphoma
Section 2 - Mature T-Cell and NK-Cell Neoplasms
  • Chapter 28 - NK-Cell Neoplasms
  • Chapter 29 - Epstein-Barr Virus–Positive Systemic T-Lymphoproliferative Disorders and Related Lymphoproliferations of Childhood
  • Chapter 30 - T-Cell Large Granular Lymphocytic Leukemia
  • Chapter 31 - T-Cell Prolymphocytic Leukemia
  • Chapter 32 - Adult T-Cell Leukemia/Lymphoma
  • Chapter 33 - Hepatosplenic T-Cell Lymphoma
  • Chapter 34 - Peripheral T-Cell Lymphoma, Not Otherwise Specified
  • Chapter 35 - Angioimmunoblastic T-Cell Lymphoma
  • Chapter 36 - Anaplastic Large Cell Lymphoma, ALK Positive and ALK Negative
  • Chapter 37 - Enteropathy-Associated T-Cell Lymphoma and Other Primary Intestinal T-Cell Lymphomas
  • Chapter 38 - Mycosis Fungoides and S�zary Syndrome
  • Chapter 39 - Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorders
  • Chapter 40 - Primary Cutaneous T-Cell Lymphomas
Section 3 - Precursor B- and T-Cell Neoplasms
  • Chapter 41 - Precursor B- and T-Cell Neoplasms
  • Chapter 42 - Acute Leukemias of Ambiguous Lineage
Part IV - Myeloid Neoplasms
  • Chapter 43 - Principles of Classification of Myeloid Neoplasms
  • Chapter 44 - The Myelodysplastic Syndromes
  • Chapter 45 - Acute Myeloid Leukemia
  • Chapter 46 - Myeloproliferative Neoplasms
  • Chapter 47 - Myelodysplastic/Myeloproliferative Neoplasms
  • Chapter 48 - Mastocytosis
  • Chapter 49 - Eosinophilia and Chronic Eosinophilic Leukemia, Including Myeloid/Lymphoid Neoplasms with Eosinophilia and Abnormalities of PDGFRA, PDGFRB, and FGFR1
  • Chapter 50 - Blastic Plasmacytoid Dendritic Cell Neoplasm
Part V - Histiocytic Proliferations
  • Chapter 51 - Nonneoplastic Histiocytic Proliferations of Lymph Nodes and Bone Marrow
  • Chapter 52 - Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma
  • Chapter 53 - Other Histiocytic and Dendritic Cell Neoplasms
Part VI - Immunodeficiency Disorders
  • Chapter 54 - The Pathology of Primary Immunodeficiencies
  • Chapter 55 - Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorders
  • Chapter 56 - Hematopathology of Human Immunodeficiency Virus (HIV) Infection
Part VII - Site-Specific Issues in the Diagnosis of Lymphoma and Leukemia
  • Chapter 57 - Bone Marrow Evaluation for Lymphoma
  • Chapter 58 - Evaluation of the Bone Marrow After Therapy
  • Chapter 59 - Nonhematopoietic Neoplasms of the Bone Marrow
  • Chapter 60 - Nonlymphoid Lesions of the Lymph Nodes
  • Chapter 61 - Spleen
  • Chapter 62 - Diagnosis of Lymphoma in Extranodal Sites Other Than Skin
Appendix: Staining Techniques
  • Setup
  • Staining Procedures
  • Stains

Product Details
  • Hardcover: 1072 pages
  • Publisher: Saunders; 1 Har/Psc edition (September 21, 2010)
  • Language: English
  • ISBN-10: 0721600409
  • ISBN-13: 978-0721600406
List Price: $329.00

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