Although many books have addressed clinical aspects of cardiovascular diseases, systemic arterial hypertension and basic science progress about structural and functional studies on systemic arteries (e.g., coronary, cerebral, and other peripheral arteries and microcirculation), very few books have focused on the pulmonary circulation and pulmonary vascular disease. Given the significant differences between the pulmonary and systemic vasculature and between systemic and pulmonary vascular diseases, it is urgent to have a comprehensive reference book specifically designated to describe a) basic structure and function of the pulmonary vasculature or the pulmonary circulation, b) pathophysiology of the pulmonary circulatory system, and c) clinical aspects (diagnosis, treatment, and prevention) of pulmonary vascular diseases. Textbook of Pulmonary Vascular Disease is therefore designed for and is of special interest to a) clinicians (pulmonologists, cardiologists, intensive care physicians, cardiothoracic and vascular surgeons, and emergency physicians), b) physician-scientists and basic-science researchers in the fields of cardiopulmonary and critical care medicine, vascular physiology and pathophysiology, translational medical research, and bioengineering, c) healthcare workers in cardiopulmonary and critical care medicine, and d) clinical and research fellows as well as residents, medical and graduate students. Textbook of Pulmonary Vascular Disease combines basic scientific concepts and knowledge on the pulmonary circulation with clinical diagnosis and treatment on pulmonary vascular diseases. Textbook of Pulmonary Vascular Disease is unique in that no book currently available i) focuses on elucidating the cellular and molecular regulation of normal pulmonary vasculature and the pathogenic mechanisms of pulmonary vascular diseases, ii) includes advanced techniques and technology for basic and clinical research, and iii) includes conventional and molecular approaches currently available for diagnosis and treatment of patients with pulmonary vascular diseases. Another feature of the book is the inclusion of surgical approaches for treatment of pulmonary vascular diseases, which have not been well described in previously published books. Textbook of Pulmonary Vascular Disease is divided into five parts. Part 1 (Structure, Function and Regulation), consisting of nine sections and twenty-nine chapters, is designated for basic knowledge and recent findings related to pulmonary vascular structure, function, and regulation at levels of molecule, cell, tissue, organ and system. Part 2 (Methodological Approaches for Research) is composed of six sections and sixteen chapters that are designed to provide a basic knowledge and spectrum on the techniques and technology that are commonly used to study genetic, molecular, cellular, systemic and pathophysiological aspects of the pulmonary vasculature. Part 3 (Pathology and Pathobiology) includes four sections and nineteen chapters that discuss the potential mechanisms or sequence of events involved in the initiation and progression of abnormalities in the pulmonary vasculature in patients with pulmonary vascular disease. Part 4 (Pulmonary Vascular Diseases) consists of nine sections and thirty-two chapters devoted to describe pathogenesis, epidemiology and pathophysiology of almost all of the pulmonary vascular diseases identified so far by the World Health Organization (WHO). One of the sections is specifically designated to describe pulmonary vascular disease in pediatric patients. Part 5 (Diagnosis and Treatment) includes three sections and twenty chapters designed to illustrate, in details, the diagnostic and therapeutic procedures currently used for patients with pulmonary vascular disease. Textbook of Pulmonary Vascular Disease is written by more than 220 experts in the field including physicians, surgeons, epidemiologists, bioinformaticians, nurses, physician scientists and investigators. All of the contributors are actively involved in clinical, physiological, and pathophysiological studies on the pulmonary circulation and pulmonary vascular diseases. The vast majority of authors are recognized experts in the research area of the topic on which the chapter is based with many contributors also Fellows of the Pulmonary Vascular Research Institute, a not-for-profit, international scientific association focused on the pulmonary circulation and pulmonary vascular disease. Founded in 2007, the Pulmonary Vascular Research Institute (PVRI) has assembled clinical, epidemiological, translational and basic scientists from around the world to perform research and advance education regarding pulmonary vascular disease and right heart failure. There is a focus on performing research in and providing education and treatment to underserved populations of the world. The unique strength of the PVRI is that it brings together a multidisciplinary faculty from around the world within a single focused institute. PVRI members have the expertise to conduct basic, translational, and clinical research at a level that no single academic institution can offer. The publication of an authoritative textbook on pulmonary vascular disease was an initial goal of the Institute. Textbook of Pulmonary Vascular Disease will not only serve as a reference book for physicians, surgeons, private practitioners, translational medical researchers, clinical and research fellows, and medical and graduate students, but also can be used as a guidance manual for technical and marketing personnel in pharmaceutical and biotechnological companies, that are interested in clinical and basic science research in cardiopulmonary diseases, pulmonary vascular diseases, vascular biology, and lung/heart transplantation. This book will also allow readers to foster new concepts and new collaboration and cooperation among clinicians, physician scientists and investigators so as to further understand the pathogenic mechanisms of pulmonary vascular disease and develop novel therapeutic approaches for the disease.
Contents
Part I Structure, Function and Regulation
The Human Pulmonary Circulation
1 The Human Pulmonary Circulation: Historical Introduction
Structure and Function of the Pulmonary Circulation
2 Microcirculation of the Lung: Functional and Anatomic Aspects
3 Pulmonary Vascular Development
4 Pulmonary Vascular Function
5 Pulmonary Vascular Mechanics
6 Modeling of the Pulmonary Vasculature
7 Metabolic and Clearance Function at the Pulmonary Microvascular Endothelial Surface in Pulmonary Hypertension
Pulmonary Vasomotor Tone, Vascular Reactivity, and Vascular Permeability
8 The Influence of the Major Vasoactive Mediators Relevant to the Pathogenesis of Pulmonary Hypertension
9 The Normal Fetal and Neonatal Pulmonary Circulation
10 Excitation–Contraction Coupling and Regulation of Pulmonary Vascular Contractility
11 Endothelial Regulation of Pulmonary Vascular Tone
12 Acute Lung Injury: The Injured Lung Endothelium, Therapeutic Strategies for Barrier Protection, and Vascular Biomarkers
Signal Transduction
13 Ion Channels and Transporters in the Pulmonary Vasculature: A Focus on Smooth Muscle
14 Receptor-Mediated Signal Transduction and Cell Signaling
15 Role of Calcium as a Second Messenger in Signaling: A Focus on Endothelium
16 Caveolae and Signaling in Pulmonary Vascular Endothelial and Smooth Muscle Cells
Oxygen Sensing and Reactive Oxygen Specials in the Lung
17 The Chemistry of Biological Gases
18 Role of Oxygen-Derived Species in the Regulation of Pulmonary Vascular Tone
19 Mitochondrial Reactive Oxygen Species and Redox State in Pulmonary Vascular O2 Sensing
Cell Proliferation and Apoptosis
20 Cellular and Molecular Mechanisms of Pulmonary Vascular Smooth Muscle Cell Proliferation
21 Role of Ca2+ in Vascular Smooth Muscle Gene Expression and Proliferation
22 Biochemistry and Cellular Mechanisms of Apoptosis in Vascular Smooth Muscle and Endothelial Cells
Coagulation, Thrombosis, and Fibrinolysis
23 The Coagulation Cascade and Its Regulation
24 Platelets in Pulmonary Vascular Physiology and Pathology
25 Lysis and Organization of Pulmonary Thromboemboli
Interactions of Pulmonary Vascular Cells with Circulating Blood Cells
26 Interactions of Leukocytes and Coagulation Factors with the Vessel Wall
27 Interaction of the Plasminogen System with the Vessel Wall
28 Endothelial Apoptosis and Repair in Pulmonary Arterial Hypertension
The Systemic Circulation in the Lung
29 Bronchial Arterial Circulation in the Human
Part II Methodological Approaches for Research In vivo and Genetic Animal Models
30 Animal Models of Pulmonary Hypertension
31 Transgenic and Gene-Targeted Mouse Models for Pulmonary Hypertension
32 Animal Models of Increased Lung Vascular Permeability
Morphological, Functional, and Regulatory Approaches
33 Isolation and Culture of Pulmonary Vascular Smooth Muscle and Endothelial Cells
34 Conventional Patch Clamp Techniques and High-Throughput Patch Clamp Recordings on a Chip for Measuring Ion Channel Activity
35 Measurement of Pulmonary Vascular Structure and Pulmonary Blood Distribution by Multidetector-Row Computed Tomography and Magnetic Resonance Imaging Techniques
Molecular Biological Techniques
36 Quantification of DNA, RNA, and Protein Expression
37 Gene Cloning, Transfection, and Mutagenesis
38 Approaches for Manipulation of Gene Expression
Genomic, Proteomic and Bioinformatical Approaches
39 Bioinformatics, Genomics, and Functional Genomics: Overview
40 Genomic Applications to Study Pulmonary Hypertension
41 Proteomics and Functional Proteomics
Stem Cells
42 Maintenance, Propagation, and Differentiation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells
43 Identification of Adult Stem and Progenitor Cells in the Pulmonary Vasculature
44 Differentiation of Embryonic Stem Cells to Vascular Cell Lineages
Clinical Research Approaches
45 Statistics and Clinical Data Analysis: A Reference Guide
Part III Pathology and Pathobiology
Hypoxia and Hyperoxia in the Development of Pulmonary Hypertension
46 Hypoxic Pulmonary Vasoconstriction
47 Pathogenic Roles of Ca2+ and Ion Channels in Hypoxia-Mediated Pulmonary Hypertension
48 Roles of Endothelium-Derived Vasoactive and Mitogenic Factors in the Development of Chronic-Hypoxia-Mediated
Pulmonary Hypertension
49 Oxygen-Sensitive Transcription Factors and Hypoxia-Mediated Pulmonary Hypertension
50 Developmental Regulation of Pulmonary Vascular Oxygen Sensing
51 Pulmonary Vascular Remodeling by High Oxygen
Pulmonary Vasoconstriction and Vascular Remodeling in Pulmonary Hypertension
52 Pulmonary Vascular Remodeling: Cellular and Molecular Mechanisms
53 Carbon Monoxide and Heme Oxygenase in the Regulation of Pulmonary Vascular Function and Structure
54 Shear Stress, Cell Signaling, and Pulmonary Vascular Remodeling
55 Pulmonary Hypertension and the Extracellular Matrix
56 Role of Progenitor Cells in Pulmonary Vascular Remodeling
57 Receptor Signaling in Pulmonary Arterial Hypertension
Endothelium and Thrombosis in the Development of Pulmonary Hypertension
58 Role of Endothelium in the Development of Pulmonary Hypertension
59 Coagulation and the Vessel Wall in Pulmonary Embolism
Pulmonary Edema and Acute Lung Injury
60 Alveolar Epithelial Fluid Transport in Lung Injury
61 High-Altitude Pulmonary Edema
62 Statins and Acute Lung Injury
63 Genomics of Acute Lung Injury and Vascular Barrier Dysfunction
64 Ventilator-Induced Mechanical Stress and Lung Vascular Dysfunction
Part IV Pulmonary Vascular Diseases
Nomenclature, Classification and Epidemiology of Pulmonary Hypertension
65 Classification of Pulmonary Hypertension: History and Perspectives
66 Epidemiology of Pulmonary Arterial Hypertension
67 Air Pollution and the Pulmonary Vasculature
Pulmonary Arterial Hypertension
68 Idiopathic Pulmonary Arterial Hypertension
69 Genetics of Familial and Idiopathic Pulmonary Arterial Hypertension
70 Pulmonary Arterial Hypertension Related to Scleroderma and Collagen Vascular Diseases
71 Pathology and Management of Portopulmonary Hypertension
72 Pathobiology and Treatment of Pulmonary Hypertension in HIV Disease
73 Pulmonary Arterial Hypertension Secondary to Anorexigensand Other Drugs and Toxins
74 Pulmonary Arterial Hypertension Related to Gaucher’s Disease, Sarcoidosis, and Other Disorders
Pulmonary Arterial Hypertension in Pediatric Patients
75 Pediatric Pulmonary Hypertension: An Integrated View from Pediatric Subspecialists
76 Persistent Pulmonary Hypertension of the Newborn: Mechanisms and Treatment
77 The Pulmonary Circulation in Congenital Heart Disease
78 Pulmonary Hypertension Secondary to Congenital Systemic-to-Pulmonary (Left-to-Right) Shunts
79 Surgical Evaluation of Congenital-Heart-Disease-Associated Pulmonary Hypertension
Pulmonary Venous Hypertension
80 Pulmonary Veno-occlusive Disease
81 Left Ventricular Diastolic Heart Function and Pulmonary Hypertension
Pulmonary Hypertension Associated with Hypoxia and Hypoxemia
82 Pulmonary Hypertension Associated with Chronic Obstructive Pulmonary Diseases
83 Pulmonary Hypertension Associated with Interstitial Lung Disease
84 High-Altitude Pulmonary Hypertension
85 Pulmonary Hypertension and Congenital Heart Defects at High Altitude
Pulmonary Hypertension due to Chronic Thrombotic and/or Embolic Disease
86 Pulmonary Embolism and Deep Vein Thrombosis
87 Pulmonary Hypertension Due to Pulmonary Embolism and Thromboembolic Obstruction of Proximal and Distal Pulmonary Arteries
88 Risk Factors for Chronic Thromboembolic Pulmonary Hypertension
89 Evaluation of Small-Vessel Arteriopathy in Chronic Thromboembolic Pulmonary Hypertension
90 Hemolytic-Anemia-Associated Pulmonary Hypertension: Sickle-Cell-Disease- and Thalassemia-Associated Pulmonary Hypertension
Pulmonary Hypertension due to Disorders Directly Affecting the Pulmonary Vasculature
91 Pulmonary Hypertension Due to Schistosomiasis
92 Pulmonary Hypertension Due to Capillary Hemangiomatosis
Right Heart Dysfunction and Pulmonary Hypertension
93 Molecular Basis of Right Ventricular Hypertrophy and Failure in Pulmonary Vascular Disease
94 Right Ventricular Dysfunction in Pulmonary Hypertension
Other Disorders of the Pulmonary Circulation
95 Large Vessel Pulmonary Arteritis
96 Tumors of the Pulmonary Vascular Bed
97 Cor Pulmonale
98 Pregnancy and Contraception in Patients with Pulmonary Arterial Hypertension
Part V Diagnosis and Treatment
Diagnostic Approaches for Pulmonary Vascular Diseases
99 Cardiac Catheterization in the Patient with Pulmonary Hypertension
100 Imaging of Pulmonary Vascular Diseases
101 Histological and Pathological Diagnosis of Pulmonary Hypertension: Pathological Classification of Pulmonary Vascular Lesions
102 Echocardiography in Pulmonary Vascular Disease
Therapeutic Interventions for Pulmonary Vascular Diseases
103 Calcium Channel Blockers in the Treatment of Pulmonary Arterial Hypertension
104 Prostacyclin and Prostaglandins
105 Endothelin Receptor Antagonists for the Treatment of Pulmonary Arterial Hypertension
106 Phosphodiesterase Inhibitors in the Treatment of Pulmonary Hypertension
107 Nitric Oxide for Children
108 The Serotonin System as a Therapeutic Target in Pulmonary Hypertension
109 Combination Therapy for Pulmonary Arterial Hypertension
110 Thrombolytic and Anticoagulant Therapy for Pulmonary Embolism and Chronic Thromboembolic Pulmonary Hypertension
111 Nursing Care of Patients with Pulmonary Arterial Hypertension
Interventional and Surgical Approaches to Treatment of Pulmonary Vascular Diseases
112 Atrial Septostomy
113 Evaluation of Patients with Chronic Thromboembolic Pulmonary Hypertension for Pulmonary Endarterectomy
114 Pulmonary Endarterectomy
115 Evaluation of Patients with Pulmonary Hypertension for Lung Transplantation
116 Lung Transplantation for Pulmonary Hypertension
117 Living-Donor Lobar Lung Transplantation for Pulmonary Arterial Hypertension
118 Results of Lung Transplantation
Index
Book Details
- Hardcover: 1690 pages
- Publisher: Springer; 1st edition (May 3, 2011)
- Language: English
- ISBN-10: 0387874283
- ISBN-13: 978-0387874289
- Product Dimensions: 11.2 x 8.5 x 2.9 inches