Nasal Polyposis: Pathogenesis, Medical and Surgical Treatment

The knowledge about epidemiology, etiology, pathogenesis, and pathophysiology of nasal polyposis has increased in many aspects but a comprehensive summary of the present status has been missing. Everything about why polyps develop and how to treat them can be found in this book. Another great advantage of this book is that controversial issues such as fungal-induced inflammation and Staphylococcus aureus-derived Superantigens in nasal polyp disease or functional endoscopic sinus surgery and nasalization are also discussed.
The first section of this book reflect the history, epidemiology, and inflammatory characteristics, followed by tools for diagnosis – pathology and radiology. While some purposed CRS causes such as biofilms, fungi, and superantigens are not confined to NP, they nevertheless may contribute to inflammation in NP and these and other etiologic topics are addressed by experts in the field in the following section. Fungal cause of CRS inflammation is controversial and we present two chapters on this reflecting two points of view. Other disorders are known for their association with NP and include association with asthma and lower airway disorders, systemic vasculitis syndromes, and cystic fibrosis. A chapter is also devoted to the differential diagnosis of NP in children and preceeds special aspects of NP evaluation including olfaction and nitric oxide assessment.
The second half of this book is devoted to therapeutic approaches to NP. The medical therapies of steroids, antibiotics, antifungals, and aspirin desensitization are each addressed in their own chapter. The treatment of NP has been referred to as sandwich therapy by my friend and a contributor, Wytske Fokkens MD, PhD. This reflects the need for medical therapy before and after the surgical therapy which is sandwiched between.
From the first chapter of this book we know that surgical therapy for NP dates back at least to the fifth century BCE, and Hippocrates. The last section of this book returns to surgical methods, including endoscopic sinus surgery, nasalization, aggressive sinus marsupialization, and the modified Lothrop procedure. Despite medical interventions and the most brilliant surgery, every rhinologist and every expert has patients with recalcitrant or rapidly recurrent disease. There is still much to understand in the management of this complex and diverse disorder. We hope this book will allow you to be the best practioner possible in the care of your patient with NP.

1 History of Nasal Polyposis
2 Epidemiology of Nasal Polyps
3 Pathology of Nasal Polyps
4 The Inflammatory Process in Nasal Polyposis: Genetics, Molecular Biology, and Electrophysiology
5 Eosinophil
6 Radiologic Imaging of Nasal Polyposis
7 Pathogenesis and Pathophysiology of Nasal Polyps
8 Mucin Expression in Nasal Polyps
9 Biofilms
10 Staphylococcus-aureus-derived Superantigens in Nasal Polyp Disease
11 Fungal-Induced Inflammation and Nasal Polyps
12 Categorization of Nasal Polyps
13 Nasal Polyps and Lower Respiratory Tract Relationship
14 Nasal Polyp, Analgesic Intolerance, and Bronchial Hyperreactivity
15 Allergic Fungal Sinusitis
16 Vasculitis Including Churg–Strauss Syndrome
17 Nasal Polyps in Cystic Fibrosis
18 Nasal Polyposis in Children: A Differential Diagnosis and Algorithm
19 Olfaction and Nasal Polyposis
20 New Areas for Investigation: Nitric Oxide
21 Current Concepts on the Pathomechanisms of Chronic Rhinosinusitis and Nasal Polyps
22 Relapses After Surgery and Their Prevention
23 Cortison Therapy in Nasal Polyposis
24 Antifungal Treatment (Topical/Systemic)
25 Antibiotic Treatment (Topical/Systemic)
26 Aspirin Intolerance
27 Where Are We in the Medical Treatment of Nasal Polyps
28 Anesthetic Management in Nasal Polypectomy
29 Surgical Treatment of Nasal Polyposis
30 Nasalisation in the Surgical Treatment of Nasal Polyposis
31 Reasons for Failure and Complications of Surgery in Diffuse Nasal Polyposis
32 Nasal Polyposis: Aggressive Sinus Marsupialization Including the Endoscopic Modified Lothrop Procedure
33 Evaluation of Surgical Treatments

Book Details

  • Hardcover: 311 pages
  • Publisher: Springer; 1st edition (November 4, 2010)
  • Language: English
  • ISBN-10: 3642114113
  • ISBN-13: 978-3642114113
  • Product Dimensions: 10.4 x 7.8 x 0.9 inches
List Price: $189.00

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